Drug interactions
Captopril-hydrochlorothiazide + Imipramine
Severity: Moderate
Captopril-hydrochlorothiazide and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can cause orthostatic hypotension through alpha-adrenergic blockade, adding to the blood pressure lowering effect of captopril and hydrochlorothiazide. Older adults are at greater risk of dizziness and falls.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 blockade by the tricyclic antidepressant and the ACE inhibitor/diuretic.
What to do
Monitor blood pressure including standing measurements, and advise slow postural changes. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Imipramine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can cause orthostatic hypotension through alpha-adrenergic blockade, adding to the blood pressure lowering effect of captopril and hydrochlorothiazide. Older adults are at greater risk of dizziness and falls.
How serious is the interaction between Captopril-hydrochlorothiazide and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing measurements, and advise slow postural changes. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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