Drug interactions
Captopril-hydrochlorothiazide + Insulin degludec
Severity: Moderate
Captopril-hydrochlorothiazide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Captopril may in contrast enhance insulin sensitivity, so glycemic control can shift in either direction.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides impair insulin secretion and sensitivity, partly via hypokalemia, while ACE inhibition improves insulin sensitivity.
What to do
Monitor blood glucose when starting, stopping or changing doses and adjust insulin as needed. Keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Insulin degludec?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Captopril may in contrast enhance insulin sensitivity, so glycemic control can shift in either direction.
How serious is the interaction between Captopril-hydrochlorothiazide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing doses and adjust insulin as needed. Keep potassium in the normal range.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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