Drug interactions
Captopril-hydrochlorothiazide + Isocarboxazid
Severity: Moderate
Captopril-hydrochlorothiazide and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isocarboxazid commonly causes orthostatic hypotension, and captopril-hydrochlorothiazide adds blood-pressure lowering through the diuretic hydrochlorothiazide and the ACE inhibitor captopril. Dizziness, syncope and falls are the practical concern, especially in older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive hypotension: MAOI-related autonomic blockade plus diuretic volume depletion and antihypertensive effect
What to do
Check sitting and standing blood pressure after starting or adjusting either drug, start the antihypertensive at a low dose, and counsel on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Isocarboxazid?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isocarboxazid commonly causes orthostatic hypotension, and captopril-hydrochlorothiazide adds blood-pressure lowering through the diuretic hydrochlorothiazide and the ACE inhibitor captopril. Dizziness, syncope and falls are the practical concern, especially in older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sitting and standing blood pressure after starting or adjusting either drug, start the antihypertensive at a low dose, and counsel on rising slowly.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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