Drug interactions
Captopril-hydrochlorothiazide + Minoxidil
Severity: Moderate
Captopril-hydrochlorothiazide and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Minoxidil is a potent vasodilator that causes sodium and water retention and reflex tachycardia, so it is typically given with a diuretic. Adding captopril and hydrochlorothiazide increases blood pressure lowering, which is often intended but can cause excessive hypotension.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Minoxidil belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from vasodilation, ACE inhibition and diuresis.
What to do
Monitor blood pressure, heart rate and fluid status, and adjust doses to avoid hypotension and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Minoxidil
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Minoxidil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Minoxidil is a potent vasodilator that causes sodium and water retention and reflex tachycardia, so it is typically given with a diuretic. Adding captopril and hydrochlorothiazide increases blood pressure lowering, which is often intended but can cause excessive hypotension.
How serious is the interaction between Captopril-hydrochlorothiazide and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and fluid status, and adjust doses to avoid hypotension and edema.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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