Drug interactions
Captopril-hydrochlorothiazide + Morphine
Severity: Moderate
Captopril-hydrochlorothiazide and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine can cause hypotension through histamine release and vasodilation, which may be additive with captopril and hydrochlorothiazide. Risk is greater in volume-depleted patients and with parenteral dosing.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Morphine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from opioid-induced vasodilation and ACE inhibitor plus diuretic action.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting or increasing morphine. Correct volume depletion and reduce doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Morphine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Morphine can cause hypotension through histamine release and vasodilation, which may be additive with captopril and hydrochlorothiazide. Risk is greater in volume-depleted patients and with parenteral dosing.
How serious is the interaction between Captopril-hydrochlorothiazide and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting or increasing morphine. Correct volume depletion and reduce doses if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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