Drug interactions
Captopril-hydrochlorothiazide + Ofloxacin
Severity: Minor
Captopril-hydrochlorothiazide and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is eliminated mainly by the kidneys including tubular secretion, so reduced renal function or competition could raise its levels slightly. Diuretic-induced electrolyte disturbance such as hypokalemia may also add to fluoroquinolone QT-prolonging risk.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion, plus electrolyte disturbance from the thiazide that may heighten QT risk.
What to do
Monitor renal function and correct potassium and magnesium deficits, adjusting ofloxacin dose in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ofloxacin?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is eliminated mainly by the kidneys including tubular secretion, so reduced renal function or competition could raise its levels slightly. Diuretic-induced electrolyte disturbance such as hypokalemia may also add to fluoroquinolone QT-prolonging risk.
How serious is the interaction between Captopril-hydrochlorothiazide and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and correct potassium and magnesium deficits, adjusting ofloxacin dose in renal impairment.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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