Drug interactions
Captopril-hydrochlorothiazide + Phenelzine
Severity: Moderate
Captopril-hydrochlorothiazide and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine commonly causes orthostatic hypotension and may markedly enhance the effect of captopril and hydrochlorothiazide. Severe hypotension and falls can result, particularly in older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition impairs sympathetic vascular tone, adding to the hypotensive effects of ACE inhibitors and diuretics.
What to do
Monitor supine and standing blood pressure when starting or changing doses. Reduce the antihypertensive dose if orthostatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Phenelzine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine commonly causes orthostatic hypotension and may markedly enhance the effect of captopril and hydrochlorothiazide. Severe hypotension and falls can result, particularly in older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or changing doses. Reduce the antihypertensive dose if orthostatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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