Drug interactions
Captopril-hydrochlorothiazide + Prednisolone
Severity: Moderate
Captopril-hydrochlorothiazide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and corticosteroids promote potassium loss. Together they may cause hypokalemia, and corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive effect.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide action and the mineralocorticoid effect of prednisolone, plus sodium and fluid retention.
What to do
Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid therapy. Supplement potassium if needed; the ACE inhibitor component partly offsets potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Prednisolone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and corticosteroids promote potassium loss. Together they may cause hypokalemia, and corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive effect.
How serious is the interaction between Captopril-hydrochlorothiazide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid therapy. Supplement potassium if needed; the ACE inhibitor component partly offsets potassium loss.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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