Drug interactions
Captopril-hydrochlorothiazide + Quinine
Severity: Moderate
Captopril-hydrochlorothiazide and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and quinine can both cause electrolyte disturbances relevant to QT prolongation, since quinine prolongs the QT interval and thiazide-induced hypokalemia or hypomagnesemia increases arrhythmia risk. A renal transport interaction raising quinine levels has been suggested but is of uncertain importance.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia add to quinine QT prolongation; possible competition for renal tubular secretion.
What to do
Check potassium and magnesium before and during quinine therapy and correct deficits. Obtain an ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Quinine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and quinine can both cause electrolyte disturbances relevant to QT prolongation, since quinine prolongs the QT interval and thiazide-induced hypokalemia or hypomagnesemia increases arrhythmia risk. A renal transport interaction raising quinine levels has been suggested but is of uncertain importance.
How serious is the interaction between Captopril-hydrochlorothiazide and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during quinine therapy and correct deficits. Obtain an ECG if other QT-prolonging drugs are present.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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