Drug interactions
Captopril-hydrochlorothiazide + Ropinirole
Severity: Moderate
Captopril-hydrochlorothiazide and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropinirole can cause orthostatic hypotension and syncope, which may be intensified by an ACE inhibitor and thiazide diuretic. The risk is greatest at initiation and during dose titration.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ropinirole belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor sitting and standing blood pressure during ropinirole titration. Reduce the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ropinirole?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropinirole can cause orthostatic hypotension and syncope, which may be intensified by an ACE inhibitor and thiazide diuretic. The risk is greatest at initiation and during dose titration.
How serious is the interaction between Captopril-hydrochlorothiazide and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure during ropinirole titration. Reduce the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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