Drug interactions
Captopril-hydrochlorothiazide + Salmeterol
Severity: Moderate
Captopril-hydrochlorothiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and hydrochlorothiazide can each lower serum potassium, and together hypokalemia may be more pronounced. This can promote arrhythmias, particularly in patients with heart disease or high-dose beta-agonist use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and thiazide urinary potassium loss.
What to do
Monitor serum potassium in patients on regular salmeterol, especially with other risk factors. Replace potassium as needed; the captopril component partly offsets losses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Salmeterol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and hydrochlorothiazide can each lower serum potassium, and together hypokalemia may be more pronounced. This can promote arrhythmias, particularly in patients with heart disease or high-dose beta-agonist use.
How serious is the interaction between Captopril-hydrochlorothiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on regular salmeterol, especially with other risk factors. Replace potassium as needed; the captopril component partly offsets losses.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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