Drug interactions
Captopril-hydrochlorothiazide + Selegiline
Severity: Moderate
Captopril-hydrochlorothiazide and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline, particularly at higher doses or as a transdermal patch, can cause orthostatic hypotension. With an ACE inhibitor and thiazide, blood pressure may fall further.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor blood pressure, including standing readings, after starting or changing selegiline. Reduce antihypertensive doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Selegiline?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline, particularly at higher doses or as a transdermal patch, can cause orthostatic hypotension. With an ACE inhibitor and thiazide, blood pressure may fall further.
How serious is the interaction between Captopril-hydrochlorothiazide and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, after starting or changing selegiline. Reduce antihypertensive doses if symptomatic.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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