Drug interactions
Captopril-hydrochlorothiazide + Tadalafil
Severity: Moderate
Captopril-hydrochlorothiazide and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilating properties and can add to the blood pressure lowering of captopril and hydrochlorothiazide. Symptomatic hypotension may occur.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects via PDE5 inhibition.
What to do
Monitor blood pressure after starting tadalafil and advise patients to report dizziness or fainting. Adjust antihypertensive therapy if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Tadalafil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilating properties and can add to the blood pressure lowering of captopril and hydrochlorothiazide. Symptomatic hypotension may occur.
How serious is the interaction between Captopril-hydrochlorothiazide and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tadalafil and advise patients to report dizziness or fainting. Adjust antihypertensive therapy if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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