Drug interactions
Captopril-hydrochlorothiazide + Timolol
Severity: Moderate
Captopril-hydrochlorothiazide and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol adds to the antihypertensive effect of captopril and hydrochlorothiazide, which may be beneficial but can cause hypotension or bradycardia. Ophthalmic timolol has less effect but can be absorbed systemically. Beta-blockers may also modestly increase potassium.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering; beta-blockade may slightly impair cellular potassium uptake.
What to do
Monitor blood pressure, heart rate, and serum potassium when starting or adjusting timolol. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Timolol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol adds to the antihypertensive effect of captopril and hydrochlorothiazide, which may be beneficial but can cause hypotension or bradycardia. Ophthalmic timolol has less effect but can be absorbed systemically. Beta-blockers may also modestly increase potassium.
How serious is the interaction between Captopril-hydrochlorothiazide and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, and serum potassium when starting or adjusting timolol. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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