Drug interactions
Captopril-hydrochlorothiazide + Tretinoin
Severity: Minor
Captopril-hydrochlorothiazide and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and tretinoin, particularly topical, increases skin sensitivity to sunlight. Together they may increase the risk of sunburn or phototoxic skin reactions in sun-exposed skin.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects on the skin.
What to do
Advise strict sun protection with broad-spectrum sunscreen and protective clothing, and review skin reactions at follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Tretinoin?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is a recognized photosensitizer, and tretinoin, particularly topical, increases skin sensitivity to sunlight. Together they may increase the risk of sunburn or phototoxic skin reactions in sun-exposed skin.
How serious is the interaction between Captopril-hydrochlorothiazide and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun protection with broad-spectrum sunscreen and protective clothing, and review skin reactions at follow-up.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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