Drug interactions
Carbachol + Diphenoxylate-atropine
Severity: Minor
Carbachol and Diphenoxylate-atropine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist and atropine is a muscarinic antagonist, so atropine may blunt the intended effects of carbachol. The significance depends on route; ophthalmic carbachol has little systemic exposure.
What this interaction means in plain words
Carbachol and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced cholinergic response if systemic carbachol is used; no action usually needed for topical ophthalmic use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Diphenoxylate-atropine?
MediHelp rates the interaction as minor. Carbachol and Diphenoxylate-atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist and atropine is a muscarinic antagonist, so atropine may blunt the intended effects of carbachol. The significance depends on route; ophthalmic carbachol has little systemic exposure.
How serious is the interaction between Carbachol and Diphenoxylate-atropine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced cholinergic response if systemic carbachol is used; no action usually needed for topical ophthalmic use.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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