Drug interactions
Carbachol + Imipramine
Severity: Minor
Carbachol and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist, and imipramine's antimuscarinic action may oppose its effect. The result may be reduced cholinergic response, such as less miosis or reduced intraocular pressure lowering when carbachol is used in the eye.
What this interaction means in plain words
Carbachol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a muscarinic agonist and a drug with antimuscarinic properties.
What to do
No routine change is needed; monitor therapeutic response to carbachol, such as intraocular pressure, and adjust if the effect is blunted.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Imipramine?
MediHelp rates the interaction as minor. Carbachol and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist, and imipramine's antimuscarinic action may oppose its effect. The result may be reduced cholinergic response, such as less miosis or reduced intraocular pressure lowering when carbachol is used in the eye.
How serious is the interaction between Carbachol and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor therapeutic response to carbachol, such as intraocular pressure, and adjust if the effect is blunted.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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