Drug interactions
Carbachol + Nortriptyline
Severity: Minor
Carbachol and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a muscarinic agonist and nortriptyline has antimuscarinic properties, so the two can oppose each other. Nortriptyline may blunt the intended effect of carbachol, for example on pupil constriction or intraocular pressure.
What this interaction means in plain words
Carbachol and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Nortriptyline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor the therapeutic response to carbachol, especially if it is used for glaucoma or miosis. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Nortriptyline?
MediHelp rates the interaction as minor. Carbachol and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a muscarinic agonist and nortriptyline has antimuscarinic properties, so the two can oppose each other. Nortriptyline may blunt the intended effect of carbachol, for example on pupil constriction or intraocular pressure.
How serious is the interaction between Carbachol and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the therapeutic response to carbachol, especially if it is used for glaucoma or miosis. No dose change is usually needed.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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