Drug interactions
Carbachol + Scopolamine
Severity: Moderate
Carbachol and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a muscarinic and nicotinic agonist, whereas scopolamine blocks muscarinic receptors, so each can oppose the other's effects. Scopolamine may reduce carbachol's effects such as miosis, reduced intraocular pressure or bladder stimulation.
What this interaction means in plain words
Carbachol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbachol belongs to Miscellaneous; Scopolamine belongs to Respiratory.
Why it happens
Direct pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid combining when a cholinergic effect is the therapeutic goal, or monitor therapeutic response (e.g. intraocular pressure or urinary function) and adjust therapy if effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Scopolamine?
MediHelp rates the interaction as moderate. Carbachol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbachol is a muscarinic and nicotinic agonist, whereas scopolamine blocks muscarinic receptors, so each can oppose the other's effects. Scopolamine may reduce carbachol's effects such as miosis, reduced intraocular pressure or bladder stimulation.
How serious is the interaction between Carbachol and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a cholinergic effect is the therapeutic goal, or monitor therapeutic response (e.g. intraocular pressure or urinary function) and adjust therapy if effect is lost.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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