Drug interactions
Carbamazepine + Carvedilol
Severity: Moderate
Carbamazepine and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong enzyme inducer and may lower carvedilol exposure. Reduced blood pressure or heart rate control may result.
What this interaction means in plain words
Carbamazepine and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Carvedilol belongs to Cardiovascular.
Why it happens
Carbamazepine induction of hepatic metabolism increases carvedilol clearance.
What to do
Monitor blood pressure and heart rate and increase carvedilol dose if response is inadequate. Reassess if carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Carvedilol?
MediHelp rates the interaction as moderate. Carbamazepine and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong enzyme inducer and may lower carvedilol exposure. Reduced blood pressure or heart rate control may result.
How serious is the interaction between Carbamazepine and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and increase carvedilol dose if response is inadequate. Reassess if carbamazepine is withdrawn.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Albuterol, Amifostine, Amiodarone. The full list is on the Carvedilol page.
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