Drug interactions
Carbamazepine + Chlordiazepoxide
Severity: Moderate
Carbamazepine and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes and can lower chlordiazepoxide concentrations, reducing its anxiolytic or withdrawal-controlling effect. Both drugs also cause sedation, so a loss of effect and an additive CNS effect may both occur.
What this interaction means in plain words
Carbamazepine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by carbamazepine accelerates chlordiazepoxide metabolism, plus additive CNS depression.
What to do
Monitor clinical response and adjust the chlordiazepoxide dose if efficacy declines. Watch for sedation and recheck when carbamazepine is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Carbamazepine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes and can lower chlordiazepoxide concentrations, reducing its anxiolytic or withdrawal-controlling effect. Both drugs also cause sedation, so a loss of effect and an additive CNS effect may both occur.
How serious is the interaction between Carbamazepine and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adjust the chlordiazepoxide dose if efficacy declines. Watch for sedation and recheck when carbamazepine is changed or stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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