Drug interactions
Carbamazepine + Cortisone
Severity: Moderate
Carbamazepine and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can accelerate corticosteroid clearance and reduce glucocorticoid effect. This may cause inadequate replacement in adrenal insufficiency or loss of anti-inflammatory control.
What this interaction means in plain words
Carbamazepine and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases hepatic metabolism of corticosteroids.
What to do
Monitor clinical response and increase the cortisone dose if needed. In adrenal insufficiency, watch for symptoms of under-replacement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Cortisone?
MediHelp rates the interaction as moderate. Carbamazepine and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can accelerate corticosteroid clearance and reduce glucocorticoid effect. This may cause inadequate replacement in adrenal insufficiency or loss of anti-inflammatory control.
How serious is the interaction between Carbamazepine and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the cortisone dose if needed. In adrenal insufficiency, watch for symptoms of under-replacement.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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