Drug interactions
Carbamazepine + Dabigatran
Severity: Major
Carbamazepine and Dabigatran: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, a P-glycoprotein inducer, lowers dabigatran plasma concentrations. This may reduce anticoagulation and increase the risk of stroke or thromboembolism.
What this interaction means in plain words
Carbamazepine and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of intestinal P-glycoprotein efflux reduces dabigatran absorption and bioavailability.
What to do
Avoid concomitant use and consider an alternative anticoagulant or anticonvulsant. Monitor for thromboembolic events if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Dabigatran?
MediHelp rates the interaction as major. Carbamazepine and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine, a P-glycoprotein inducer, lowers dabigatran plasma concentrations. This may reduce anticoagulation and increase the risk of stroke or thromboembolism.
How serious is the interaction between Carbamazepine and Dabigatran?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and consider an alternative anticoagulant or anticonvulsant. Monitor for thromboembolic events if it cannot be avoided.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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