Drug interactions
Carbamazepine + Disulfiram
Severity: Moderate
Carbamazepine and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause hepatotoxicity, so combined use may add to liver injury risk. Disulfiram may also affect carbamazepine disposition in some patients.
What this interaction means in plain words
Carbamazepine and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; a pharmacokinetic effect of disulfiram on carbamazepine metabolism is possible but not well established.
What to do
Monitor liver enzymes and carbamazepine levels at baseline and periodically. Stop therapy if hepatic injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Disulfiram?
MediHelp rates the interaction as moderate. Carbamazepine and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause hepatotoxicity, so combined use may add to liver injury risk. Disulfiram may also affect carbamazepine disposition in some patients.
How serious is the interaction between Carbamazepine and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and carbamazepine levels at baseline and periodically. Stop therapy if hepatic injury develops.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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