Drug interactions
Carbamazepine + Enalapril
Severity: Minor
Carbamazepine and Enalapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enalapril does not have an established inhibitory effect on carbamazepine metabolism. The more recognized concern is hyponatremia, which both drugs can cause, and there are isolated reports of this occurring with combinations.
What this interaction means in plain words
Carbamazepine and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Enalapril belongs to Cardiovascular.
Why it happens
No established pharmacokinetic mechanism; possible additive hyponatremia from carbamazepine-related SIADH and ACE inhibitor effects.
What to do
Monitor serum sodium after starting the combination, particularly in older patients. Check carbamazepine levels if toxicity symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Enalapril?
MediHelp rates the interaction as minor. Carbamazepine and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enalapril does not have an established inhibitory effect on carbamazepine metabolism. The more recognized concern is hyponatremia, which both drugs can cause, and there are isolated reports of this occurring with combinations.
How serious is the interaction between Carbamazepine and Enalapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium after starting the combination, particularly in older patients. Check carbamazepine levels if toxicity symptoms appear.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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