Drug interactions
Carbamazepine + Glibenclamide
Severity: Moderate
Carbamazepine and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce glyburide concentrations and weaken its glucose-lowering effect. Loss of glycemic control may occur after carbamazepine is started, and hypoglycemia may occur after it is stopped.
What this interaction means in plain words
Carbamazepine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Glibenclamide belongs to Endocrine.
Why it happens
Carbamazepine induces CYP2C9 and CYP3A4, increasing glyburide metabolism.
What to do
Monitor blood glucose and HbA1c when carbamazepine is started, changed or stopped. Adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Carbamazepine with Glibenclamide?
MediHelp rates the interaction as moderate. Carbamazepine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce glyburide concentrations and weaken its glucose-lowering effect. Loss of glycemic control may occur after carbamazepine is started, and hypoglycemia may occur after it is stopped.
How serious is the interaction between Carbamazepine and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when carbamazepine is started, changed or stopped. Adjust the glyburide dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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