Drug interactions
Carbamazepine + Heparin
Severity: Minor
Carbamazepine and Heparin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is not known to reliably alter heparin effect. Heparin is cleared mainly via the reticuloendothelial system and renally rather than by CYP enzymes, so induction should not matter.
What this interaction means in plain words
Carbamazepine and Heparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Heparin belongs to Cardiovascular.
Why it happens
No established mechanism; heparin is not significantly metabolized by enzymes induced by carbamazepine.
What to do
No specific action is needed beyond routine aPTT or anti-Xa monitoring of heparin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Heparin?
MediHelp rates the interaction as minor. Carbamazepine and Heparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is not known to reliably alter heparin effect. Heparin is cleared mainly via the reticuloendothelial system and renally rather than by CYP enzymes, so induction should not matter.
How serious is the interaction between Carbamazepine and Heparin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine aPTT or anti-Xa monitoring of heparin.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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