Drug interactions
Carbamazepine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Carbamazepine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and thiazide diuretics can lower serum sodium, and together they may cause clinically significant hyponatremia. Symptoms range from nausea and confusion to seizures.
What this interaction means in plain words
Carbamazepine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive effects on sodium loss (thiazide) and water retention via enhanced ADH effect (carbamazepine).
What to do
Check serum sodium at baseline and periodically, especially in older patients or after dose changes. Stop or change the diuretic if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Carbamazepine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and thiazide diuretics can lower serum sodium, and together they may cause clinically significant hyponatremia. Symptoms range from nausea and confusion to seizures.
How serious is the interaction between Carbamazepine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially in older patients or after dose changes. Stop or change the diuretic if sodium falls significantly.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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