Drug interactions
Carbamazepine + Ixabepilone
Severity: Major
Carbamazepine and Ixabepilone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is cleared mainly by CYP3A4, so a strong inducer such as carbamazepine can lower its exposure and reduce antitumor effect. Labeling advises avoiding strong inducers.
What this interaction means in plain words
Carbamazepine and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbamazepine induces CYP3A4, accelerating the metabolism of ixabepilone.
What to do
Use a non-inducing antiseizure drug instead of carbamazepine. If unavoidable, the ixabepilone dose may need to be increased under specialist guidance with close monitoring of tolerability and response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbamazepine and Ixabepilone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ixabepilone?
MediHelp rates the interaction as major. Carbamazepine and Ixabepilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ixabepilone is cleared mainly by CYP3A4, so a strong inducer such as carbamazepine can lower its exposure and reduce antitumor effect. Labeling advises avoiding strong inducers.
How serious is the interaction between Carbamazepine and Ixabepilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiseizure drug instead of carbamazepine. If unavoidable, the ixabepilone dose may need to be increased under specialist guidance with close monitoring of tolerability and response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
