Drug interactions
Carbamazepine + Metoclopramide intranasal
Severity: Moderate
Carbamazepine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause central nervous system adverse effects, and carbamazepine combined with metoclopramide has been associated with increased neurotoxicity. The clinical significance of the intranasal formulation is not well characterized.
What this interaction means in plain words
Carbamazepine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; additive central nervous system effects are suspected.
What to do
Monitor for neurologic effects such as drowsiness, dizziness, extrapyramidal symptoms and ataxia. Consider an alternative antiemetic or prokinetic if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Carbamazepine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause central nervous system adverse effects, and carbamazepine combined with metoclopramide has been associated with increased neurotoxicity. The clinical significance of the intranasal formulation is not well characterized.
How serious is the interaction between Carbamazepine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic effects such as drowsiness, dizziness, extrapyramidal symptoms and ataxia. Consider an alternative antiemetic or prokinetic if these occur.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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