Drug interactions
Carbamazepine + Parecoxib
Severity: Moderate
Carbamazepine and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower exposure to valdecoxib, the active metabolite of parecoxib, and reduce analgesic effect. Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9.
What this interaction means in plain words
Carbamazepine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C9, increasing valdecoxib clearance.
What to do
Monitor analgesic response and adjust pain management if effect is inadequate. Avoid exceeding the labelled maximum parecoxib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Parecoxib?
MediHelp rates the interaction as moderate. Carbamazepine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower exposure to valdecoxib, the active metabolite of parecoxib, and reduce analgesic effect. Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9.
How serious is the interaction between Carbamazepine and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust pain management if effect is inadequate. Avoid exceeding the labelled maximum parecoxib dose.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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