Drug interactions
Carbamazepine + Progesterone intravaginal
Severity: Moderate
Carbamazepine and Progesterone intravaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower progesterone exposure, though vaginal administration partly avoids first-pass metabolism. Reduced effect may compromise luteal support or endometrial protection.
What this interaction means in plain words
Carbamazepine and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbamazepine induces CYP3A4, increasing the metabolism of progesterone.
What to do
Monitor for reduced efficacy such as breakthrough bleeding or treatment failure, and consider a higher progesterone dose or non-inducing anticonvulsant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Progesterone intravaginal?
MediHelp rates the interaction as moderate. Carbamazepine and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower progesterone exposure, though vaginal administration partly avoids first-pass metabolism. Reduced effect may compromise luteal support or endometrial protection.
How serious is the interaction between Carbamazepine and Progesterone intravaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy such as breakthrough bleeding or treatment failure, and consider a higher progesterone dose or non-inducing anticonvulsant.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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