Drug interactions
Carbamazepine + Progesterone micronized
Severity: Moderate
Carbamazepine and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce oral progesterone concentrations, which may lead to inadequate endometrial protection or breakthrough bleeding.
What this interaction means in plain words
Carbamazepine and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbamazepine induces CYP3A4, increasing hepatic and intestinal metabolism of progesterone.
What to do
Monitor for breakthrough bleeding or endometrial hyperplasia when used with estrogen, and increase the progesterone dose or switch to a non-inducing anticonvulsant if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Progesterone micronized?
MediHelp rates the interaction as moderate. Carbamazepine and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce oral progesterone concentrations, which may lead to inadequate endometrial protection or breakthrough bleeding.
How serious is the interaction between Carbamazepine and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or endometrial hyperplasia when used with estrogen, and increase the progesterone dose or switch to a non-inducing anticonvulsant if needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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