Drug interactions
Carbamazepine + Rabeprazole
Severity: Minor
Carbamazepine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a potent enzyme inducer and may lower rabeprazole exposure. Rabeprazole is cleared largely non-enzymatically, so the clinical effect is likely small.
What this interaction means in plain words
Carbamazepine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C19, increasing the metabolism of the small fraction of rabeprazole cleared by these enzymes.
What to do
No routine change is needed; assess acid-suppression efficacy and increase the PPI dose if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Rabeprazole?
MediHelp rates the interaction as minor. Carbamazepine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is a potent enzyme inducer and may lower rabeprazole exposure. Rabeprazole is cleared largely non-enzymatically, so the clinical effect is likely small.
How serious is the interaction between Carbamazepine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; assess acid-suppression efficacy and increase the PPI dose if symptoms persist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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