Drug interactions
Carbamazepine + Selegiline transdermal
Severity: Contraindicated
Carbamazepine and Selegiline transdermal: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is structurally related to tricyclic compounds, and combining it with an MAO inhibitor is labeled as contraindicated because of risk of hyperpyrexia, hypertensive crisis, and seizures. Transdermal selegiline at antidepressant doses carries this risk.
What this interaction means in plain words
Carbamazepine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic effects of MAO inhibition with carbamazepine; the precise mechanism is not well established.
What to do
Avoid the combination; carbamazepine labeling requires a gap of at least 14 days after stopping an MAO inhibitor.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Carbamazepine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is structurally related to tricyclic compounds, and combining it with an MAO inhibitor is labeled as contraindicated because of risk of hyperpyrexia, hypertensive crisis, and seizures. Transdermal selegiline at antidepressant doses carries this risk.
How serious is the interaction between Carbamazepine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; carbamazepine labeling requires a gap of at least 14 days after stopping an MAO inhibitor.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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