Drug interactions
Carbamazepine + Sofosbuvir / velpatasvir
Severity: Contraindicated
Carbamazepine and Sofosbuvir / velpatasvir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine lowers sofosbuvir and velpatasvir concentrations, which may lead to failure of hepatitis C cure. Labeling advises against coadministration with potent inducers.
What this interaction means in plain words
Carbamazepine and Sofosbuvir / velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Induction of P-glycoprotein and CYP enzymes (CYP2B6, CYP2C8, CYP3A4) increases clearance and reduces absorption of both drugs.
What to do
Do not use together; switch to a non-inducing anticonvulsant before starting the antiviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as contraindicated. Carbamazepine and Sofosbuvir / velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine lowers sofosbuvir and velpatasvir concentrations, which may lead to failure of hepatitis C cure. Labeling advises against coadministration with potent inducers.
How serious is the interaction between Carbamazepine and Sofosbuvir / velpatasvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; switch to a non-inducing anticonvulsant before starting the antiviral regimen.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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