Drug interactions
Carbamazepine + Telotristat ethyl
Severity: Minor
Carbamazepine and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may reduce exposure to CYP3A4 substrates, so carbamazepine levels could fall modestly. Carbamazepine is also an autoinducer and the clinical effect is uncertain.
What this interaction means in plain words
Carbamazepine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Telotristat ethyl induces CYP3A4, potentially increasing carbamazepine metabolism.
What to do
Monitor seizure control and carbamazepine serum concentrations after starting or stopping telotristat. Adjust the carbamazepine dose if levels drop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Telotristat ethyl?
MediHelp rates the interaction as minor. Carbamazepine and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat may reduce exposure to CYP3A4 substrates, so carbamazepine levels could fall modestly. Carbamazepine is also an autoinducer and the clinical effect is uncertain.
How serious is the interaction between Carbamazepine and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and carbamazepine serum concentrations after starting or stopping telotristat. Adjust the carbamazepine dose if levels drop.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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