Drug interactions
Carbamazepine + Tiagabine
Severity: Moderate
Carbamazepine and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine markedly increases tiagabine clearance and can lower its concentrations by around half or more, potentially reducing seizure control. Higher tiagabine doses are often needed.
What this interaction means in plain words
Carbamazepine and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbamazepine induces CYP3A4, increasing tiagabine metabolism.
What to do
Titrate tiagabine to clinical response, expecting higher dose requirements. Reassess the dose if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Tiagabine?
MediHelp rates the interaction as moderate. Carbamazepine and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine markedly increases tiagabine clearance and can lower its concentrations by around half or more, potentially reducing seizure control. Higher tiagabine doses are often needed.
How serious is the interaction between Carbamazepine and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate tiagabine to clinical response, expecting higher dose requirements. Reassess the dose if carbamazepine is stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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