Drug interactions
Carbenoxolone + Ethinyl estradiol-drospirenone
Severity: Minor
Carbenoxolone and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium and fluid retention and potassium loss, while drospirenone is antimineralocorticoid. The effects are opposing, so the net effect on potassium and blood pressure is unpredictable.
What this interaction means in plain words
Carbenoxolone and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing mineralocorticoid effects: carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase while drospirenone antagonizes the mineralocorticoid receptor.
What to do
Monitor serum potassium and blood pressure when the two are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Carbenoxolone with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Carbenoxolone and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbenoxolone has mineralocorticoid-like activity causing sodium and fluid retention and potassium loss, while drospirenone is antimineralocorticoid. The effects are opposing, so the net effect on potassium and blood pressure is unpredictable.
How serious is the interaction between Carbenoxolone and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when the two are used together.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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