Drug interactions
Carbenoxolone + Gentamicin
Severity: Moderate
Carbenoxolone and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium retention and potassium loss, and gentamicin can add renal potassium and magnesium wasting. The combination may cause significant hypokalemia.
What this interaction means in plain words
Carbenoxolone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mineralocorticoid-like renal potassium excretion added to aminoglycoside-induced tubular electrolyte wasting.
What to do
Monitor serum potassium and magnesium regularly and replace deficits; consider stopping carbenoxolone if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Carbenoxolone with Gentamicin?
MediHelp rates the interaction as moderate. Carbenoxolone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium retention and potassium loss, and gentamicin can add renal potassium and magnesium wasting. The combination may cause significant hypokalemia.
How serious is the interaction between Carbenoxolone and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits; consider stopping carbenoxolone if hypokalemia develops.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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