Drug interactions
Carbenoxolone + Hydrochlorothiazide-lisinopril
Severity: Major
Carbenoxolone and Hydrochlorothiazide-lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia and may raise blood pressure. Severe hypokalemia can cause arrhythmias and muscle weakness.
What this interaction means in plain words
Carbenoxolone and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that adds to thiazide kaliuresis.
What to do
Avoid the combination where possible; otherwise monitor serum potassium and blood pressure closely and supplement potassium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Carbenoxolone with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Carbenoxolone and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to thiazide-induced hypokalemia and may raise blood pressure. Severe hypokalemia can cause arrhythmias and muscle weakness.
How serious is the interaction between Carbenoxolone and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise monitor serum potassium and blood pressure closely and supplement potassium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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