Drug interactions
Carbenoxolone + Labetalol
Severity: Moderate
Carbenoxolone and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention and hypokalemia, which can raise blood pressure. This may counteract the antihypertensive effect of labetalol.
What this interaction means in plain words
Carbenoxolone and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that opposes antihypertensive therapy.
What to do
Monitor blood pressure, fluid status and serum potassium during coadministration. Consider an alternative gastric agent if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Carbenoxolone with Labetalol?
MediHelp rates the interaction as moderate. Carbenoxolone and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention and hypokalemia, which can raise blood pressure. This may counteract the antihypertensive effect of labetalol.
How serious is the interaction between Carbenoxolone and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during coadministration. Consider an alternative gastric agent if blood pressure rises.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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