Drug interactions
Carbenoxolone + Mefenamic acid
Severity: Moderate
Carbenoxolone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and water retention and potassium loss, and NSAIDs also promote fluid retention and can worsen blood pressure. Together they may exacerbate edema, hypertension and renal strain.
What this interaction means in plain words
Carbenoxolone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium and fluid retention: carbenoxolone's mineralocorticoid-like activity plus NSAID inhibition of renal prostaglandins.
What to do
Monitor blood pressure, fluid status, serum potassium and renal function during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Carbenoxolone with Mefenamic acid?
MediHelp rates the interaction as moderate. Carbenoxolone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and water retention and potassium loss, and NSAIDs also promote fluid retention and can worsen blood pressure. Together they may exacerbate edema, hypertension and renal strain.
How serious is the interaction between Carbenoxolone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum potassium and renal function during combined use.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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