Drug interactions
Carbenoxolone + Nabumetone
Severity: Moderate
Carbenoxolone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention, hypertension and hypokalemia, and NSAIDs also promote fluid retention and can raise blood pressure. NSAIDs may also counteract its ulcer-healing purpose by causing mucosal damage.
What this interaction means in plain words
Carbenoxolone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mineralocorticoid-like effect of carbenoxolone adds to NSAID-induced sodium and fluid retention; NSAIDs injure gastric mucosa.
What to do
Monitor blood pressure, fluid status and serum potassium; consider avoiding the combination in heart failure or hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Carbenoxolone with Nabumetone?
MediHelp rates the interaction as moderate. Carbenoxolone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention, hypertension and hypokalemia, and NSAIDs also promote fluid retention and can raise blood pressure. NSAIDs may also counteract its ulcer-healing purpose by causing mucosal damage.
How serious is the interaction between Carbenoxolone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium; consider avoiding the combination in heart failure or hypertension.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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