Drug interactions
Carbenoxolone + Piroxicam
Severity: Moderate
Carbenoxolone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and water retention and hypokalemia, and NSAIDs also promote fluid retention and can reduce antihypertensive control. Together they may worsen hypertension and edema.
What this interaction means in plain words
Carbenoxolone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mineralocorticoid-like effects of carbenoxolone add to NSAID-induced renal sodium and water retention.
What to do
Monitor blood pressure, fluid status and serum potassium. Consider an alternative to one of the agents if hypertension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbenoxolone and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Carbenoxolone with Piroxicam?
MediHelp rates the interaction as moderate. Carbenoxolone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and water retention and hypokalemia, and NSAIDs also promote fluid retention and can reduce antihypertensive control. Together they may worsen hypertension and edema.
How serious is the interaction between Carbenoxolone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium. Consider an alternative to one of the agents if hypertension or edema develops.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
