Drug interactions
Carbenoxolone + Succinylcholine
Severity: Minor
Carbenoxolone and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can cause a transient rise in serum potassium, whereas carbenoxolone causes mineralocorticoid-like potassium loss. The net clinical effect is unpredictable, and hypokalemia may alter neuromuscular blockade and arrhythmia risk during anesthesia.
What this interaction means in plain words
Carbenoxolone and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium; carbenoxolone has mineralocorticoid-like activity that promotes renal potassium wasting.
What to do
Check serum potassium before anesthesia in patients taking carbenoxolone and correct any abnormality. Monitor ECG and neuromuscular function during use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Carbenoxolone with Succinylcholine?
MediHelp rates the interaction as minor. Carbenoxolone and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine can cause a transient rise in serum potassium, whereas carbenoxolone causes mineralocorticoid-like potassium loss. The net clinical effect is unpredictable, and hypokalemia may alter neuromuscular blockade and arrhythmia risk during anesthesia.
How serious is the interaction between Carbenoxolone and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before anesthesia in patients taking carbenoxolone and correct any abnormality. Monitor ECG and neuromuscular function during use.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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