Drug interactions
Carbidopa + Hydrochlorothiazide-telmisartan
Severity: Moderate
Carbidopa and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can add to the blood pressure lowering of antihypertensives and cause orthostatic hypotension. This is most relevant when dopaminergic therapy is started or increased.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from levodopa-derived dopamine and the vasodilating and volume-depleting actions of the antihypertensives.
What to do
Check standing and sitting blood pressure when starting or titrating levodopa/carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Carbidopa and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, can add to the blood pressure lowering of antihypertensives and cause orthostatic hypotension. This is most relevant when dopaminergic therapy is started or increased.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check standing and sitting blood pressure when starting or titrating levodopa/carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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