Drug interactions
Carbidopa + Hydrochlorothiazide-valsartan
Severity: Moderate
Carbidopa and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can add to the blood pressure-lowering effect of antihypertensives, so symptomatic or orthostatic hypotension may occur. This is most likely when starting dopaminergic therapy in older patients.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, mainly from levodopa-derived dopamine, with the diuretic and ARB.
What to do
Monitor standing and sitting blood pressure when starting or adjusting carbidopa-levodopa, and reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Carbidopa and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, can add to the blood pressure-lowering effect of antihypertensives, so symptomatic or orthostatic hypotension may occur. This is most likely when starting dopaminergic therapy in older patients.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting or adjusting carbidopa-levodopa, and reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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