Drug interactions
Carbidopa-entacapone-levodopa + Clevidipine
Severity: Moderate
Carbidopa-entacapone-levodopa and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa-containing therapy can lower blood pressure and cause orthostatic hypotension. Combined with the potent intravenous calcium channel blocker clevidipine, the hypotensive effect may be greater than expected.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Clevidipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering, as levodopa-derived dopamine causes vasodilation and reduces sympathetic tone.
What to do
Monitor blood pressure closely when clevidipine is titrated in patients on levodopa, and watch for orthostasis. Use the lowest effective clevidipine rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Clevidipine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa-containing therapy can lower blood pressure and cause orthostatic hypotension. Combined with the potent intravenous calcium channel blocker clevidipine, the hypotensive effect may be greater than expected.
How serious is the interaction between Carbidopa-entacapone-levodopa and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when clevidipine is titrated in patients on levodopa, and watch for orthostasis. Use the lowest effective clevidipine rate.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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