Drug interactions
Carbidopa-entacapone-levodopa + Daridorexant
Severity: Moderate
Carbidopa-entacapone-levodopa and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is a sedative-hypnotic and levodopa can cause somnolence and sudden sleep onset. Together they may increase daytime drowsiness and psychomotor impairment.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective daridorexant dose and counsel patients about daytime sedation and driving; reassess if excessive somnolence occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Daridorexant?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant is a sedative-hypnotic and levodopa can cause somnolence and sudden sleep onset. Together they may increase daytime drowsiness and psychomotor impairment.
How serious is the interaction between Carbidopa-entacapone-levodopa and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel patients about daytime sedation and driving; reassess if excessive somnolence occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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